Which oral manifestation is characterized by the presence of lesions and is linked to HIV infection?

Hairy leukoplakia is the correct answer due to its well-established association with HIV infection. This condition is characterized by the appearance of white, hairy lesions on the lateral borders of the tongue, which result from an Epstein-Barr virus (EBV) infection in immunocompromised individuals, such as those with HIV/AIDS. The lesions are often painless and can serve as an indicator of a weakened immune system often seen in people living with HIV.

In contrast, the other options do not specifically indicate an HIV infection. While herpes simplex virus (type 1) can cause oral lesions, it is not exclusively linked to HIV and can occur in immunocompetent individuals as well. Angular cheilitis is typically a result of factors like vitamin deficiencies or fungal infections and is not specifically associated with HIV. Periodontitis can occur in anyone and is linked to periodontal disease rather than being indicative of HIV status. Thus, hairy leukoplakia stands out as a significant oral manifestation that signals the presence of HIV-related immunocompromise.