What is the A1C level that signals a high risk of infection?

An A1C level above 8% indicates poor long-term glucose control, which significantly increases the risk of various complications, including infections. High blood glucose levels can impair immune function, making individuals more susceptible to infections. This occurs for several reasons, such as reduced neutrophil function and a weakened inflammatory response, which are critical for fighting off pathogens.

Additionally, elevated glucose levels can lead to conditions like neuropathy and circulatory issues, further compromising the body's ability to respond to infections. Therefore, maintaining an A1C level below this threshold is essential for reducing the risk of infections and associated complications.

The other choices represent A1C levels associated with lower risks of infection, with levels below 5.7% and between 5.7% and 6.4% generally indicating normal to pre-diabetic status, both of which are associated with a reduced risk for infections compared to the levels defined as high risk.